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Aliases TAAR5, PNR, trace amine associated receptor 5
External IDs MGI: 2685073 HomoloGene: 20850 GeneCards: 9038
RNA expression pattern
PBB GE TAAR5 221459 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 132.59 – 132.59 Mb Chr 10: 23.97 – 23.97 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Trace amine-associated receptor 5 is a protein that in humans is encoded by the TAAR5 gene.[3][4][5] In vertebrates, TAAR5 is expressed in the olfactory epithelium.[6]

Human TAAR5 (hTAAR5) is a functional trace amine-associated receptor which acts as an olfactory receptor for tertiary amines.[6][7] Trimethylamine (TMA) and N,N-dimethylethylamine are full agonists of hTAAR5.[7][8][9] The amber-woody fragrance timberol antagonizes this activity of TMA.[10] 3-Iodothyronamine acts as an inverse agonist at hTAAR5.[11]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zeng Z, Fan P, Rand E, Kyaw H, Su K, Madike V, Carter KC, Li Y (Mar 1998). "Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain". Biochem Biophys Res Commun. 242 (3): 575–8. doi:10.1006/bbrc.1997.7591. PMID 9464258. 
  4. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104. 
  5. ^ "Entrez Gene: TAAR5 trace amine associated receptor 5". 
  6. ^ a b Liberles SD (2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Curr. Opin. Neurobiol. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMID 25616211. All TAARs except TAAR1 function as olfactory receptors, based on studies in rodent, primate, and fish [4,7,10]. TAAR expression is highly enriched in the olfactory system by quantitative PCR (qPCR) analysis, with little or no expression in other tissues examined [4]. 
  7. ^ a b Zhang LS, Davies SS (April 2016). "Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions". Genome Med. 8 (1): 46. doi:10.1186/s13073-016-0296-x. PMC 4840492free to read. PMID 27102537. 
    Table 2: Microbial metabolites: their synthesis, mechanisms of action, and effects on health and disease
    Figure 1: Molecular mechanisms of action of indole and its metabolites on host physiology and disease
  8. ^ Wallrabenstein I, Kuklan J, Weber L, Zborala S, Werner M, Altmüller J, Becker C, Schmidt A, Hatt H, Hummel T, Gisselmann G (2013). "Human trace amine-associated receptor TAAR5 can be activated by trimethylamine". PLoS ONE. 8 (2): e54950. doi:10.1371/journal.pone.0054950. PMC 3564852free to read. PMID 23393561. 
  9. ^ Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T (February 2013). "Ultrasensitive detection of amines by a trace amine-associated receptor". J. Neurosci. 33 (7): 3228–39. doi:10.1523/JNEUROSCI.4299-12.2013. PMC 3711460free to read. PMID 23407976. We show that [human TAAR5] responds to the tertiary amine N,N-dimethylethylamine and to a lesser extent to trimethylamine, a structurally related agonist for mouse and rat TAAR5 (Liberles and Buck, 2006; Staubert et al., 2010; Ferrero et al., 2012). 
  10. ^ Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G (2015). "Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans". PLoS ONE. 10 (12): e0144704. doi:10.1371/journal.pone.0144704. PMC 4684214free to read. PMID 26684881. 
  11. ^ Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H (2015). "Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5". PLoS ONE. 10 (2): e0117774. doi:10.1371/journal.pone.0117774. PMID 25706283. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.