TAAR6

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TAAR6
Identifiers
AliasesTAAR6, TA4, TAR4, TAR6, TRAR4, taR-4, taR-6, trace amine associated receptor 6
External IDsMGI: 2685074 HomoloGene: 27874 GeneCards: TAAR6
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TAAR6
Genomic location for TAAR6
Band6q23.2Start132,570,322 bp[1]
End132,571,359 bp[1]
RNA expression pattern
PBB GE TAAR6 gnf1h10296 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_175067

NM_001010828

RefSeq (protein)

NP_778237

NP_001010828

Location (UCSC)Chr 6: 132.57 – 132.57 MbChr 10: 23.98 – 23.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[5][6]

Function[edit]

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146383 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045111 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMC 55357Freely accessible. PMID 11459929. 
  6. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104. 
  7. ^ Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (October 2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". Am. J. Hum. Genet. 75 (4): 624–38. doi:10.1086/424887. PMC 1182049Freely accessible. PMID 15329799. 
  8. ^ "Entrez Gene: TAAR6 trace amine associated receptor 6". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.