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Trace amine associated receptor 8
Symbols TAAR8 ; GPR102; TA5; TAR5; TRAR5; TaR-5; TaR-8
External IDs OMIM606927 MGI2685076 HomoloGene77586 IUPHAR: 172 GeneCards: TAAR8 Gene
RNA expression pattern
PBB GE TAAR8 gnf1h01258 s at tn.png
More reference expression data
Species Human Mouse
Entrez 83551 215859
Ensembl ENSG00000146385 ENSMUSG00000096442
UniProt Q969N4 Q5QD07
RefSeq (mRNA) NM_053278 NM_001010830
RefSeq (protein) NP_444508 NP_001010830
Location (UCSC) Chr 6:
132.55 – 132.55 Mb
Chr 10:
24.08 – 24.08 Mb
PubMed search [1] [2]

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene.[1][2][3] In humans, TAAR8 is the only trace amine-associated receptor known to couple to the Gi/o signaling pathway.[4]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][3]

See also[edit]


  1. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  2. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104. 
  3. ^ a b "Entrez Gene: TAAR8 trace amine associated receptor 8". 
  4. ^ Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H (2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". Int J Mol Sci 15 (11): 20638–55. doi:10.3390/ijms151120638. PMC 4264187. PMID 25391046. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.