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Protein TADA2L PDB 1x41.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TADA2A, ADA2, ADA2A, TADA2L, hADA2, KL04P, transcriptional adaptor 2A
External IDs MGI: 2144471 HomoloGene: 38834 GeneCards: TADA2A
RNA expression pattern
PBB GE TADA2L 209938 at fs.png

PBB GE TADA2L 210537 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 37.41 – 37.48 Mb Chr 11: 84.08 – 84.13 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Transcriptional adapter 2-alpha is a protein that in humans is encoded by the TADA2A gene.[3][4]


Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.[4]


TADA2L has been shown to interact with GCN5L2,[5][6] TADA3L[7][8] and Myc.[9]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (Feb 1996). "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5". Molecular and Cellular Biology. 16 (2): 593–602. doi:10.1128/mcb.16.2.593. PMC 231038Freely accessible. PMID 8552087. 
  4. ^ a b "Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like". 
  5. ^ Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL (Mar 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex". Molecular and Cellular Biology. 18 (3): 1349–58. doi:10.1128/mcb.18.3.1349. PMC 108848Freely accessible. PMID 9488450. 
  6. ^ Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL (Jan 1997). "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation". Molecular and Cellular Biology. 17 (1): 519–27. doi:10.1128/mcb.17.1.519. PMC 231776Freely accessible. PMID 8972232. 
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ Wang T, Kobayashi T, Takimoto R, Denes AE, Snyder EL, el-Deiry WS, Brachmann RK (Nov 2001). "hADA3 is required for p53 activity". The EMBO Journal. 20 (22): 6404–13. doi:10.1093/emboj/20.22.6404. PMC 125723Freely accessible. PMID 11707411. 
  9. ^ Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917Freely accessible. PMID 12660246. 

Further reading[edit]