TADA3L

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TADA3
Identifiers
Aliases TADA3, ADA3, NGG1, STAF54, TADA3L, hADA3, transcriptional adaptor 3
External IDs MGI: 1915724 HomoloGene: 4633 GeneCards: TADA3
RNA expression pattern
PBB GE TADA3L 211221 at fs.png

PBB GE TADA3L 215273 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278270
NM_006354
NM_133480
NM_133481

NM_133932

RefSeq (protein)

NP_001265199
NP_006345
NP_597814

NP_598693.1
NP_598693

Location (UCSC) Chr 3: 9.78 – 9.79 Mb Chr 6: 113.37 – 113.38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene.[3][4][5]

Function[edit]

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.[5]

Interactions[edit]

TADA3L has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. 
  4. ^ a b Wang T, Kobayashi T, Takimoto R, Denes AE, Snyder EL, el-Deiry WS, Brachmann RK (Nov 2001). "hADA3 is required for p53 activity". The EMBO Journal. 20 (22): 6404–13. doi:10.1093/emboj/20.22.6404. PMC 125723Freely accessible. PMID 11707411. 
  5. ^ a b "Entrez Gene: TADA3L transcriptional adaptor 3 (NGG1 homolog, yeast)-like". 
  6. ^ a b Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V (Nov 2002). "Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator". The Journal of Biological Chemistry. 277 (47): 45611–8. doi:10.1074/jbc.M208447200. PMID 12235159. 
  7. ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ a b Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856Freely accessible. PMID 11564863. 

Further reading[edit]