TAF12

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TAF12
Protein TAF12 PDB 1h3o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAF12, TAF2J, TAFII20, TATA-box binding protein associated factor 12
External IDs MGI: 1913714 HomoloGene: 68477 GeneCards: TAF12
RNA expression pattern
PBB GE TAF12 209463 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135218
NM_005644

NM_025579

RefSeq (protein)

NP_001128690
NP_005635

NP_079855.2
NP_079855

Location (UCSC) Chr 1: 28.59 – 28.64 Mb Chr 4: 132.27 – 132.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.[3][4]

Function[edit]

Control of transcription by RNA polymerase II involves the basal transcription machinery, which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached, whereas others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.[4]

Interactions[edit]

TAF12 has been shown to interact with TAF9[5] and Transcription initiation protein SPT3 homolog.[5]

References[edit]

Further reading[edit]