TAF13

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TAF13
Protein TAF13 PDB 1bh8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAF13, TAF(II)18, TAF2K, TAFII-18, TAFII18, TATA-box binding protein associated factor 13
External IDs MGI: 1913500 HomoloGene: 4126 GeneCards: TAF13
RNA expression pattern
PBB GE TAF13 205966 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005645

NM_025444

RefSeq (protein)

NP_005636

NP_079720.1
NP_079720

Location (UCSC) Chr 1: 109.06 – 109.08 Mb Chr 3: 108.57 – 108.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.[3][4]

Function[edit]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6.[4]

Interactions[edit]

TAF13 has been shown to interact with TAF15,[5] TAF11,[3][6] TAF10[3] and TATA binding protein.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c d Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I (May 1995). "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID". EMBO J. 14 (7): 1520–31. PMC 398239Freely accessible. PMID 7729427. 
  4. ^ a b "Entrez Gene: TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa". 
  5. ^ Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. 18 (3): 1489–97. PMC 108863Freely accessible. PMID 9488465. 
  6. ^ Birck C, Poch O, Romier C, Ruff M, Mengus G, Lavigne AC, Davidson I, Moras D (Jul 1998). "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family". Cell. 94 (2): 239–49. doi:10.1016/S0092-8674(00)81423-3. PMID 9695952. 

Further reading[edit]