TAF6

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TAF6
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAF6, MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85, TATA-box binding protein associated factor 6
External IDs MGI: 109129 HomoloGene: 7561 GeneCards: TAF6
RNA expression pattern
PBB GE TAF6 203572 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190415
NM_005641
NM_139122
NM_139123
NM_139315

NM_009315

RefSeq (protein)

NP_001177344
NP_005632
NP_647476

NP_033341.1
NP_033341

Location (UCSC) Chr 7: 100.11 – 100.12 Mb Chr 5: 138.18 – 138.19 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.[3]

Function[edit]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.[4]

Interactions[edit]

TAF6 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mathé G, Schwarzenberg L, Halle-Pannenko O, Simmler MC (January 1977). "Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy". Ann N Y Acad Sci. 277 (00): 467–84. doi:10.1111/j.1749-6632.1976.tb41721.x. PMID 826207. 
  4. ^ "Entrez Gene: TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa". 
  5. ^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812Freely accessible. PMID 10523658. 
  6. ^ Tao Y, Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder RG (March 1997). "Specific interactions and potential functions of human TAFII100". J. Biol. Chem. 272 (10): 6714–21. doi:10.1074/jbc.272.10.6714. PMID 9045704. 
  7. ^ Pointud JC, Mengus G, Brancorsini S, Monaco L, Parvinen M, Sassone-Corsi P, Davidson I (May 2003). "The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation". J. Cell. Sci. 116 (Pt 9): 1847–58. doi:10.1242/jcs.00391. PMID 12665565. 
  8. ^ Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (June 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC 146709Freely accessible. PMID 9153318. 
  9. ^ Ruppert S, Wang EH, Tjian R (March 1993). "Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation". Nature. 362 (6416): 175–9. doi:10.1038/362175a0. PMID 7680771. 

Further reading[edit]