TAF8

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TAF8
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAF8, 43, II, TAF, TAFII-43, TAFII43, TBN, TATA-box binding protein associated factor 8
External IDs MGI: 1926879 HomoloGene: 11094 GeneCards: TAF8
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138572

NM_022015

RefSeq (protein)

NP_612639

NP_071298.1
NP_071298

Location (UCSC) Chr 6: 42.05 – 42.09 Mb Chr 17: 47.49 – 47.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.[3]

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

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