TANK (gene)

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PDB 1kzz EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TANK, I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator
External IDs MGI: 107676 HomoloGene: 3081 GeneCards: TANK
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for TANK
Genomic location for TANK
Band 2q24.2 Start 161,136,908 bp[1]
End 161,236,221 bp[1]
RNA expression pattern
PBB GE TANK 209451 at fs.png

PBB GE TANK 210458 s at fs.png

PBB GE TANK 207616 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 161.14 – 161.24 Mb Chr 2: 61.58 – 61.65 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.[5][6][7]


The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.[7]


TANK (gene) has been shown to interact with TANK-binding kinase 1,[8][9] IKBKE,[10] TRAF2,[5][8][9][10] IKBKG[11] and TRAF3.[5][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136560 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064289 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b c Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654Freely accessible. PMID 8710854. 
  6. ^ Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G (October 1996). "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 11085–90. doi:10.1073/pnas.93.20.11085. PMC 38288Freely accessible. PMID 8855313. 
  7. ^ a b "Entrez Gene: TANK TRAF family member-associated NFKB activator". 
  8. ^ a b c Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  9. ^ a b Pomerantz JL, Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". The EMBO Journal. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732Freely accessible. PMID 10581243. 
  10. ^ a b Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes to Cells. 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890. 
  11. ^ Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". The Journal of Biological Chemistry. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833. 

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