TARBP2

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TARBP2
Protein TARBP2 PDB 2cpn.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TARBP2, LOQS, TRBP, TRBP1, TRBP2, RISC loading complex RNA binding subunit
External IDs MGI: 103027 HomoloGene: 7562 GeneCards: TARBP2
RNA expression pattern
PBB GE TARBP2 203677 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004178
NM_134323
NM_134324

NM_001253795
NM_009319

RefSeq (protein)

NP_004169
NP_599150
NP_599151

NP_033345.2
NP_001240724
NP_033345

Location (UCSC) Chr 12: 53.5 – 53.51 Mb Chr 15: 102.52 – 102.52 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene.[3][4]

Function[edit]

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.[4]

Interactions[edit]

TARBP2 has been shown to interact with Protein kinase R[5][6] and RBM14.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gatignol A, Buckler-White A, Berkhout B, Jeang KT (Mar 1991). "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR". Science. 251 (5001): 1597–600. doi:10.1126/science.2011739. PMID 2011739. 
  4. ^ a b "Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2". 
  5. ^ Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N (Oct 1995). "Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo". Proceedings of the National Academy of Sciences of the United States of America. 92 (21): 9445–9. doi:10.1073/pnas.92.21.9445. PMC 40818Freely accessible. PMID 7568151. 
  6. ^ Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A (Sep 2001). "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression". The Journal of Biological Chemistry. 276 (36): 33899–905. doi:10.1074/jbc.M103584200. PMID 11438532. 
  7. ^ Iwasaki T, Chin WW, Ko L (Sep 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal of Biological Chemistry. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112. 

Further reading[edit]