TAS2R16

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TAS2R16
Identifiers
AliasesTAS2R16, T2R16, taste 2 receptor member 16, BGLPT
External IDsOMIM: 604867 MGI: 2681247 HomoloGene: 9660 GeneCards: TAS2R16
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for TAS2R16
Genomic location for TAS2R16
Band7q31.32|7q31Start122,994,704 bp[1]
End122,995,700 bp[1]
RNA expression pattern
PBB GE TAS2R16 221444 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016945

NM_207022

RefSeq (protein)

NP_058641

NP_996905

Location (UCSC)Chr 7: 122.99 – 123 MbChr 6: 23.97 – 23.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TAS2R16 (taste receptor, type 2, member 16) is a human gene that encodes for a receptor that may play a role in the perception of bitterness.[5][6]

The TAS2R16 gene is located on the long (q) arm of chromosome 7 at position 31.1 - 31.3, from base pair 122,228,764 to base pair 122,229,639.

Clinical significance[edit]

Variants of this gene have been linked to an increased risk for alcohol dependence.[7]

There is an East African origin for high salicin sensitivity, and thus sensitivity to bitterness in people from this region, with this phenotype matched to TAS2R16 variants.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128519 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043865 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. 
  6. ^ Drewnowski A (2001). "The science and complexity of bitter taste". Nutr Rev. 59 (6): 163–9. doi:10.1111/j.1753-4887.2001.tb07007.x. PMID 11444592. 
  7. ^ Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM (2006). "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence". Am. J. Hum. Genet. 78 (1): 103–11. doi:10.1086/499253. PMC 1380207Freely accessible. PMID 16385453. 
  8. ^ Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA (2014). "Origin and Differential Selection of Allelic Variation at TAS2R16 Associated with Salicin Bitter Taste Sensitivity in Africa". Mol Biol Evol. 31 (2): 288–302. doi:10.1093/molbev/mst211. PMC 3907056Freely accessible. PMID 24177185. 

Further reading[edit]

External links[edit]