TAX1BP3

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TAX1BP3
Protein TAX1BP3 PDB 2KG2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAX1BP3, TIP-1, TIP1, Tax1 binding protein 3
External IDs MGI: 1923531 HomoloGene: 8749 GeneCards: TAX1BP3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014604
NM_001204698

NM_029564

RefSeq (protein)

NP_001191627
NP_055419

NP_083840.1
NP_083840

Location (UCSC) Chr 17: 3.66 – 3.67 Mb Chr 11: 73.18 – 73.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tax1-binding protein 3 is a protein that in humans is encoded by the TAX1BP3 gene.[3][4][5] This name is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV)which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP. TIP1, as it is also known, is a PDZ domain containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol.


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  4. ^ Touchman JW, Anikster Y, Dietrich NL, Maduro VV, McDowell G, Shotelersuk V, Bouffard GG, Beckstrom-Sternberg SM, Gahl WA, Green ED (Mar 2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion". Genome Res. 10 (2): 165–73. doi:10.1101/gr.10.2.165. PMC 310836Freely accessible. PMID 10673275. 
  5. ^ "Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3". 

Further reading[edit]