TBPL1

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TBP-like 1
Identifiers
Symbols TBPL1 ; MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2
External IDs OMIM605521 MGI1339946 HomoloGene3577 GeneCards: TBPL1 Gene
RNA expression pattern
PBB GE TBPL1 208398 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9519 237336
Ensembl ENSG00000028839 ENSMUSG00000071359
UniProt P62380 P62340
RefSeq (mRNA) NM_001253676 NM_011603
RefSeq (protein) NP_001240605 NP_035733
Location (UCSC) Chr 6:
133.95 – 133.99 Mb
Chr 10:
22.7 – 22.73 Mb
PubMed search [1] [2]

TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.[1][2][3][4]

Function[edit]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.[4]

Interactions[edit]

TBPL1 has been shown to interact with GTF2A1.[5][6]

References[edit]

  1. ^ Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T (Feb 1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochemical and Biophysical Research Communications 255 (1): 137–42. doi:10.1006/bbrc.1999.0159. PMID 10082669. 
  2. ^ Rabenstein MD, Zhou S, Lis JT, Tjian R (Apr 1999). "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family". Proceedings of the National Academy of Sciences of the United States of America 96 (9): 4791–6. doi:10.1073/pnas.96.9.4791. PMC 21770. PMID 10220372. 
  3. ^ Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE (Apr 2005). "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP". Molecular and Cellular Biology 25 (7): 2632–43. doi:10.1128/MCB.25.7.2632-2643.2005. PMC 1061635. PMID 15767669. 
  4. ^ a b "Entrez Gene: TBPL1 TBP-like 1". 
  5. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13720–5. doi:10.1073/pnas.96.24.13720. PMC 24131. PMID 10570139. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.