TCEB3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ELOA
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ELOA, EloA, SIII, SIII p110, TCEB3A, TCEB3, transcription elongation factor B subunit 3, elongin A
External IDs MGI: 1351315 HomoloGene: 37746 GeneCards: ELOA
RNA expression pattern
PBB GE TCEB3 202818 s at fs.png

PBB GE TCEB3 213604 at fs.png

PBB GE TCEB3 202819 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003198

NM_013736

RefSeq (protein)

NP_003189

NP_038764.2
NP_038764

Location (UCSC) Chr 1: 23.74 – 23.76 Mb Chr 4: 136 – 136.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription elongation factor B polypeptide 3 is a protein that in humans is encoded by the TCEB3 gene.[3][4][5]

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Aso T, Mokady N, Haque D, Conaway RC, Conaway JW (Mar 1996). "Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1". Genomics. 30 (2): 393–4. PMID 8586449. 
  4. ^ Aso T, Lane WS, Conaway JW, Conaway RC (Oct 1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science. 269 (5229): 1439–43. doi:10.1126/science.7660129. PMID 7660129. 
  5. ^ a b "Entrez Gene: TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)". 

Further reading[edit]