TCF/LEF family

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The TCF/LEF family is a group of transcription factors which bind to DNA through a high mobility group domain. They are involved in the Wnt signaling pathway, where they recruit the coactivator beta-catenin to enhancer elements of genes they target. They can also recruit members of the Groucho family of corepressors.[1]

Human members[edit]


  1. ^ Brantjes H, Barker N, van Es J, Clevers H (February 2002). "TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling". Biol. Chem. 383 (2): 255–61. doi:10.1515/BC.2002.027. PMID 11934263.