HNF1B

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HNF1B
Protein TCF2 PDB 2da6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HNF1B, FJHN, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1, HNF-1-beta, HNF1 homeobox B
External IDs MGI: 98505 HomoloGene: 396 GeneCards: 6928
Genetically Related Diseases
Disease Name References
diabetes mellitus type 2
endometrial cancer
prostate cancer
RNA expression pattern
PBB GE TCF2 205313 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000458
NM_001165923
NM_001304286
NM_006481

NM_001291268
NM_001291269
NM_009330

RefSeq (protein)

NP_000449.1
NP_001159395.1
NP_001291215.1
NP_001159395.1

NP_001278197.1
NP_001278198.1
NP_033356.2

Location (UCSC) Chr 17: 37.69 – 37.75 Mb Chr 11: 83.85 – 83.91 Mb
PubMed search [4] [5]
Wikidata
View/Edit Human View/Edit Mouse

HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene.

Function[edit]

TCF2 encodes transcription factor 2, a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.[1]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.