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T-cell leukemia/lymphoma 1A
Protein TCL1A PDB 1jsg.png
PDB rendering based on 1jsg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TCL1A ; TCL1
External IDs OMIM186960 MGI1097166 HomoloGene7565 GeneCards: TCL1A Gene
RNA expression pattern
PBB GE TCL1A 39318 at tn.png
PBB GE TCL1A 209995 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8115 21432
Ensembl ENSG00000100721 ENSMUSG00000041359
UniProt P56279 P56280
RefSeq (mRNA) NM_001098725 NM_001289468
RefSeq (protein) NP_001092195 NP_001276397
Location (UCSC) Chr 14:
95.71 – 95.71 Mb
Chr 12:
105.22 – 105.22 Mb
PubMed search [1] [2]

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.[1][2][3]


TCL1A has been shown to interact with AKT1[4][5][6] and AKT2.[4][5]


  1. ^ Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A 86 (2): 602–6. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489. 
  2. ^ Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072. 
  3. ^ "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A". 
  4. ^ a b Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444. 
  5. ^ a b Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986. 
  6. ^ French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899. 

Further reading[edit]