Teratocarcinoma-derived growth factor 1

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AliasesTDGF1, CR, CRGF, CRIPTO, teratocarcinoma-derived growth factor 1, CR-1
External IDsMGI: 98658 HomoloGene: 2416 GeneCards: TDGF1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TDGF1
Genomic location for TDGF1
Band3p21.31Start46,574,534 bp[1]
End46,582,457 bp[1]
RNA expression pattern
PBB GE TDGF1 206286 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 46.57 – 46.58 MbChr 9: 110.94 – 110.95 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Teratocarcinoma-derived growth factor 1 is a protein that in humans is encoded by the TDGF1 gene.[5][6] The protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241186 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032494 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dono R, Montuori N, Rocchi M, De Ponti-Zilli L, Ciccodicola A, Persico MG (Oct 1991). "Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence". Am J Hum Genet. 49 (3): 555–65. PMC 1683146. PMID 1882841.
  6. ^ Scognamiglio B, Baldassarre G, Cassano C, Tucci M, Montuori N, Dono R, Lembo G, Barra A, Lago CT, Viglietto G, Rocchi M, Persico MG (Jul 1999). "Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1". Cytogenet Cell Genet. 84 (3–4): 220–4. doi:10.1159/000015263. PMID 10393436.
  7. ^ "Entrez Gene: TDGF1 teratocarcinoma-derived growth factor 1".

Further reading[edit]