TDIQ

TDIQ
Identifiers
	IUPAC name 5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline;
CAS Number	15052-05-8;
PubChem CID	2752332;
CompTox Dashboard (EPA)	DTXSID00933985 ;
Chemical and physical data
Formula	C10H11NO2
Molar mass	177.199 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c23OCOc2cc1CCNCc1c3;
	(verify)

TDIQ (also known as 6,7-Methylenedioxy-1,2,3,4-tetrahydroisoquinoline or MDTHIQ) is a drug used in scientific research, which has anxiolytic and anorectic effects in animals.^[1]^[2] It has an unusual effects profile in animals, with the effects generalising to cocaine and partially to MDMA and ephedrine,^[3] but the effects did not generalise to amphetamine and TDIQ does not have any stimulant effects.^[4] It is thought these effects are mediated via a partial agonist action at Alpha-2 adrenergic receptors, and TDIQ has been suggested as a possible drug for the treatment of cocaine dependence.^[5]

References

^ Young R, Rothman RB, Rangisetty JB, Partilla JS, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of "snacks" in mice". Pharmacology, Biochemistry, and Behavior. 84 (1): 74–83. doi:10.1016/j.pbb.2006.04.007. PMID 16750261.
^ Young R, Batkai S, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice". Pharmacology, Biochemistry, and Behavior. 84 (1): 62–73. doi:10.1016/j.pbb.2006.04.006. PMID 16750844.
^ Young R, Glennon RA (2002). "The stimulus effect of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline is similar to that of cocaine but different from that of amphetamine". Pharmacology, Biochemistry, and Behavior. 71 (1–2): 205–13. doi:10.1016/S0091-3057(01)00666-9. PMID 11812524.
^ Glennon RA, Young R, Rangisetty JB (May 2002). "Further characterization of the stimulus properties of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline". Pharmacology, Biochemistry, and Behavior. 72 (1–2): 379–87. doi:10.1016/S0091-3057(01)00768-7. PMID 11900809.
^ Young R (2007). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): discovery, pharmacological effects, and therapeutic potential". CNS Drug Reviews. 13 (4): 405–22. doi:10.1111/j.1527-3458.2007.00022.x. PMID 18078426.

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[pmid16750261-1] Young R, Rothman RB, Rangisetty JB, Partilla JS, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of "snacks" in mice". Pharmacology, Biochemistry, and Behavior. 84 (1): 74–83. doi:10.1016/j.pbb.2006.04.007. PMID 16750261.

[pmid16750844-2] Young R, Batkai S, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice". Pharmacology, Biochemistry, and Behavior. 84 (1): 62–73. doi:10.1016/j.pbb.2006.04.006. PMID 16750844.

[pmid11812524-3] Young R, Glennon RA (2002). "The stimulus effect of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline is similar to that of cocaine but different from that of amphetamine". Pharmacology, Biochemistry, and Behavior. 71 (1–2): 205–13. doi:10.1016/S0091-3057(01)00666-9. PMID 11812524.

[pmid11900809-4] Glennon RA, Young R, Rangisetty JB (May 2002). "Further characterization of the stimulus properties of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline". Pharmacology, Biochemistry, and Behavior. 72 (1–2): 379–87. doi:10.1016/S0091-3057(01)00768-7. PMID 11900809.

[pmid18078426-5] Young R (2007). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): discovery, pharmacological effects, and therapeutic potential". CNS Drug Reviews. 13 (4): 405–22. doi:10.1111/j.1527-3458.2007.00022.x. PMID 18078426.

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See also

References