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TEA domain family member 1 (SV40 transcriptional enhancer factor)
Protein TEAD1 PDB 2hzd.png
PDB rendering based on 2hzd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TEAD1 ; AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1; TEF-1
External IDs OMIM189967 MGI101876 HomoloGene2418 GeneCards: TEAD1 Gene
Species Human Mouse
Entrez 7003 21676
Ensembl ENSG00000187079 ENSMUSG00000055320
UniProt P28347 P30051
RefSeq (mRNA) NM_021961 NM_001166584
RefSeq (protein) NP_068780 NP_001160056
Location (UCSC) Chr 11:
12.67 – 12.94 Mb
Chr 7:
112.68 – 112.91 Mb
PubMed search [1] [2]

Transcriptional enhancer factor TEF-1 is a protein that in humans is encoded by the TEAD1 gene.[1][2][3][4]


TEAD1 is a member of the mammalian TEAD transcription factor family (initially named the transcriptional enhancer factor (TEF) family), which contain the TEA/ATTS DNA-binding domain.[5]


TEAD1 has been shown to interact with MEF2C,[6] Serum response factor[7] and MAX.[8]


  1. ^ Xiao JH, Davidson I, Matthes H, Garnier JM, Chambon P (May 1991). "Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1". Cell 65 (4): 551–68. doi:10.1016/0092-8674(91)90088-G. PMID 1851669. 
  2. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009. 
  3. ^ Fossdal R, Jonasson F, Kristjansdottir GT, Kong A, Stefansson H, Gosh S, Gulcher JR, Stefansson K (May 2004). "A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)". Human Molecular Genetics 13 (9): 975–81. doi:10.1093/hmg/ddh106. PMID 15016762. 
  4. ^ "Entrez Gene: TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)". 
  5. ^ Bürglin TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–2. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. 
  6. ^ Maeda T, Gupta MP, Stewart AF (Jun 2002). "TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters". Biochemical and Biophysical Research Communications 294 (4): 791–7. doi:10.1016/S0006-291X(02)00556-9. PMID 12061776. 
  7. ^ Gupta M, Kogut P, Davis FJ, Belaguli NS, Schwartz RJ, Gupta MP (Mar 2001). "Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1". The Journal of Biological Chemistry 276 (13): 10413–22. doi:10.1074/jbc.M008625200. PMID 11136726. 
  8. ^ Gupta MP, Amin CS, Gupta M, Hay N, Zak R (Jul 1997). "Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression". Molecular and Cellular Biology 17 (7): 3924–36. doi:10.1128/mcb.17.7.3924. PMC 232245. PMID 9199327. 

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