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TEA domain family member 2
PDB 2hzd EBI.png
PDB rendering based on 2hzd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TEAD2 ; ETF; TEAD-2; TEF-4; TEF4
External IDs OMIM601729 MGI104904 HomoloGene19662 GeneCards: TEAD2 Gene
Species Human Mouse
Entrez 8463 21677
Ensembl ENSG00000074219 ENSMUSG00000030796
UniProt Q15562 P48301
RefSeq (mRNA) NM_001256658 NM_001285498
RefSeq (protein) NP_001243587 NP_001272427
Location (UCSC) Chr 19:
49.34 – 49.36 Mb
Chr 7:
45.22 – 45.23 Mb
PubMed search [1] [2]

Transcriptional enhancer factor TEF-4 also known as TEA domain family member 2 (TEAD-2) is a protein that in humans is encoded by the TEAD2 gene.[1][2] TEAD-2 is a transcription factor.


TEAD2 is a member of the mammalian TEAD transcription factor family (initially named the transcriptional enhancer factor (TEF) family), which contain the TEA/ATTS DNA-binding domain.[3]

Clinical significance[edit]

Recent animal models indicating a possible association of TEAD2 with anencephaly.[4]


  1. ^ Jacquemin P, Hwang JJ, Martial JA, Dollé P, Davidson I (September 1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain". J. Biol. Chem. 271 (36): 21775–85. doi:10.1074/jbc.271.36.21775. PMID 8702974. 
  2. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (January 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009. 
  3. ^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. 
  4. ^ Kaneko KJ, Kohn MJ, Liu C, Depamphilis ML (2007). "Transcription factor TEAD2 is involved in neural tube closure". Genesis 45 (9): 577–87. doi:10.1002/dvg.20330. PMC 2765819. PMID 17868131. 

Further reading[edit]

External links[edit]