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TEA domain family member 3
Protein TEAD3 PDB 2hzd.png
PDB rendering based on 2hzd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TEAD3 ; DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5
External IDs OMIM603170 MGI109241 HomoloGene81821 GeneCards: TEAD3 Gene
RNA expression pattern
PBB GE TEAD3 209454 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7005 21678
Ensembl ENSG00000007866 ENSMUSG00000002249
UniProt Q99594 P70210
RefSeq (mRNA) NM_003214 NM_001098226
RefSeq (protein) NP_003205 NP_001091696
Location (UCSC) Chr 6:
35.47 – 35.5 Mb
Chr 17:
28.33 – 28.35 Mb
PubMed search [1] [2]

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.[1][2][3]


This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[4] It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[5] Translation of this protein is initiated at a non-AUG (AUA) start codon.[3]


  1. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009. 
  2. ^ Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898. 
  3. ^ a b "Entrez Gene: TEAD3 TEA domain family member 3". 
  4. ^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. 
  5. ^ Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448. 

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