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For Tecta, a brand of a proton pump inhibitor drug, see Pantoprazole.
Tectorin alpha
Symbols TECTA ; DFNA12; DFNA8; DFNB21
External IDs OMIM602574 MGI109575 HomoloGene3955 GeneCards: TECTA Gene
RNA expression pattern
PBB GE TECTA 221296 at tn.png
More reference expression data
Species Human Mouse
Entrez 7007 21683
Ensembl ENSG00000109927 ENSMUSG00000037705
UniProt O75443 O08523
RefSeq (mRNA) NM_005422 NM_009347
RefSeq (protein) NP_005413 NP_033373
Location (UCSC) Chr 11:
121.1 – 121.19 Mb
Chr 9:
42.33 – 42.4 Mb
PubMed search [1] [2]

Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.[1][2][3]

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.[3]


  1. ^ Hughes DC, Legan PK, Steel KP, Richardson GP (Apr 1998). "Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness". Genomics 48 (1): 46–51. doi:10.1006/geno.1997.5159. PMID 9503015. 
  2. ^ Verhoeven K, Van Laer L, Kirschhofer K, Legan PK, Hughes DC, Schatteman I, Verstreken M, Van Hauwe P, Coucke P, Chen A, Smith RJ, Somers T, Offeciers FE, Van de Heyning P, Richardson GP, Wachtler F, Kimberling WJ, Willems PJ, Govaerts PJ, Van Camp G (May 1998). "Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment". Nat Genet 19 (1): 60–2. doi:10.1038/ng0598-60. PMID 9590290. 
  3. ^ a b "Entrez Gene: TECTA tectorin alpha". 

Further reading[edit]