TENC1

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TNS2
Protein TENC1 PDB 2dkq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDs MGI: 2387586 HomoloGene: 37077 GeneCards: 23371
RNA expression pattern
PBB GE TENC1 212494 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015319
NM_170754
NM_198316

NM_153533

RefSeq (protein)

NP_056134.2
NP_736610.2
NP_938072.1

NP_705761.2

Location (UCSC) Chr 12: 53.05 – 53.06 Mb Chr 15: 102.1 – 102.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[1]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[1]

Interactions[edit]

TENC1 has been shown to interact with AXL receptor tyrosine kinase.[2]

References[edit]

  1. ^ a b "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)". 
  2. ^ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. (United States) 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648. 

Further reading[edit]