TENC1

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TNS2
Protein TENC1 PDB 2dkq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDs MGI: 2387586 HomoloGene: 37077 GeneCards: TNS2
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TNS2
Genomic location for TNS2
Band 12q13.13 Start 53,046,969 bp[1]
End 53,064,372 bp[1]
RNA expression pattern
PBB GE TENC1 212494 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015319
NM_170754
NM_198316

NM_153533

RefSeq (protein)

NP_056134
NP_736610
NP_938072

NP_705761

Location (UCSC) Chr 12: 53.05 – 53.06 Mb Chr 12: 102.1 – 102.12 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[5]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[5]

Interactions[edit]

TENC1 has been shown to interact with AXL receptor tyrosine kinase.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111077 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037003 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)". 
  6. ^ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. United States. 299 (5): 793–800. ISSN 0006-291X. PMID 12470648. doi:10.1016/S0006-291X(02)02718-3. 

Further reading[edit]