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Tensin 2
Protein TENC1 PDB 2dkq.png
PDB rendering based on 2dkq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TNS2 ; C1-TEN; C1TEN; TENC1
External IDs OMIM607717 MGI2387586 HomoloGene37077 GeneCards: TNS2 Gene
RNA expression pattern
PBB GE TENC1 212494 at tn.png
More reference expression data
Species Human Mouse
Entrez 23371 209039
Ensembl ENSG00000111077 ENSMUSG00000037003
UniProt Q63HR2 Q8CGB6
RefSeq (mRNA) NM_015319 NM_153533
RefSeq (protein) NP_056134 NP_705761
Location (UCSC) Chr 12:
53.05 – 53.06 Mb
Chr 15:
102.1 – 102.12 Mb
PubMed search [1] [2]

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[1]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[1]


TENC1 has been shown to interact with AXL receptor tyrosine kinase.[2]


  1. ^ a b "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)". 
  2. ^ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. (United States) 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648. 

Further reading[edit]