TFAP4

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TFAP4
Identifiers
AliasesTFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4), transcription factor AP-4
External IDsMGI: 103239 HomoloGene: 2424 GeneCards: TFAP4
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for TFAP4
Genomic location for TFAP4
Band16p13.3Start4,257,186 bp[1]
End4,273,075 bp[1]
RNA expression pattern
PBB GE TFAP4 205688 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003223

NM_031182

RefSeq (protein)

NP_003214

NP_112459

Location (UCSC)Chr 16: 4.26 – 4.27 MbChr 16: 4.54 – 4.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.[5]

Function[edit]

Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090447 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005718 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.