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Transcription factor AP-4 (activating enhancer binding protein 4)
Symbols TFAP4 ; AP-4; bHLHc41
External IDs OMIM600743 MGI103239 HomoloGene2424 GeneCards: TFAP4 Gene
RNA expression pattern
PBB GE TFAP4 205688 at tn.png
More reference expression data
Species Human Mouse
Entrez 7023 83383
Ensembl ENSG00000090447 ENSMUSG00000005718
UniProt Q01664 Q9JIZ5
RefSeq (mRNA) NM_003223 NM_031182
RefSeq (protein) NP_003214 NP_112459
Location (UCSC) Chr 16:
4.26 – 4.27 Mb
Chr 16:
4.54 – 4.56 Mb
PubMed search [1] [2]

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.[1]


Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.