Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2gene.
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1. Late SV40 factor (LSF) also acts as an oncogene in hepatocellular carcinoma. Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).
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^Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID9685356.
Cunningham JM, Vanin EF, Tran N, Valentine M, Jane SM (Nov 1995). "The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene". Genomics. 30 (2): 398–9. PMID8586452.
Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID9685356.
Bing Z, Reddy SA, Ren Y, Qin J, Liao WS (Aug 1999). "Purification and characterization of the serum amyloid A3 enhancer factor". The Journal of Biological Chemistry. 274 (35): 24649–56. doi:10.1074/jbc.274.35.24649. PMID10455131.
Rodda S, Sharma S, Scherer M, Chapman G, Rathjen P (Feb 2001). "CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors". The Journal of Biological Chemistry. 276 (5): 3324–32. doi:10.1074/jbc.M008167200. PMID11073954.
Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI (Feb 2003). "Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease". American Journal of Medical Genetics Part B. 117B (1): 114–7. doi:10.1002/ajmg.b.10026. PMID12555245.
Chae JH, Kim CG (Feb 2003). "CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells". Molecules and Cells. 15 (1): 40–7. PMID12661759.