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Protein TGM3 PDB 1l9m.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TGM3, TGE, transglutaminase 3, UHS2
External IDs MGI: 98732 HomoloGene: 20690 GeneCards: TGM3
RNA expression pattern
PBB GE TGM3 206004 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 2.3 – 2.34 Mb Chr 2: 130.01 – 130.05 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene.[3][4][5]

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.[5]

See also[edit]

  • Proximal promoter


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wang M, Kim IG, Steinert PM, McBride OW (Mar 1995). "Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2". Genomics. 23 (3): 721–2. doi:10.1006/geno.1994.1571. PMID 7851911. 
  4. ^ Aeschlimann D, Koeller MK, Allen-Hoffmann BL, Mosher DF (Mar 1998). "Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription-polymerase chain reaction with degenerate primers". J Biol Chem. 273 (6): 3452–60. doi:10.1074/jbc.273.6.3452. PMID 9452468. 
  5. ^ a b "Entrez Gene: TGM3 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)". 

Further reading[edit]