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Available structures
PDB Ortholog search: PDBe RCSB
Aliases TGS1, NCOA6IP, PIMT, PIPMT, trimethylguanosine synthase 1
External IDs MGI: 2151797 HomoloGene: 32608 GeneCards: TGS1
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for TGS1
Genomic location for TGS1
Band 8q12.1 Start 55,773,142 bp[1]
End 55,825,448 bp[1]
RNA expression pattern
PBB GE TGS1 219231 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 55.77 – 55.83 Mb Chr 8: 3.57 – 3.62 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.[5][6][7]


TGS1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137574 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028233 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A. 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969Freely accessible. PMID 11517327. 
  6. ^ Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R (May 2002). "Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus". Mol Cell. 9 (4): 891–901. doi:10.1016/S1097-2765(02)00484-7. PMID 11983179. 
  7. ^ "Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)". 
  8. ^ a b c d Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212. 
  9. ^ Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/s0006-291x(03)01514-6. PMID 12943661. 

Further reading[edit]