T-cell lymphoma invasion and metastasis-inducing protein 1

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Protein TIAM1 PDB 1foe.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TIAM1, T-cell lymphoma invasion and metastasis-inducing protein 1, T-cell lymphoma invasion and metastasis 1
External IDs MGI: 103306 HomoloGene: 2443 GeneCards: TIAM1
RNA expression pattern
PBB GE TIAM1 213135 at fs.png

PBB GE TIAM1 206409 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 21: 31.12 – 31.56 Mb Chr 16: 89.79 – 89.98 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene.[3][4][5]


TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.


TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

Clinical significance[edit]

TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.


T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with ANK1,[6] Myc,[7] RAC1[8][9] and PPP1R9B.[10]

Tiam1 interacts also with para-cingulin, that plays a role in recruiting Tiam1 to junctions and thus activate Rac1 at epithelial junctions.[11]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1". 
  4. ^ Chen H, Antonarakis SE (Nov 1995). "Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1". Genomics. 30 (1): 123–7. doi:10.1006/geno.1995.0025. PMID 8595894. 
  5. ^ Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR (Sep 2004). "The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism". Journal of Cell Science. 117 (Pt 20): 4863–71. doi:10.1242/jcs.01367. PMID 15340013. 
  6. ^ Bourguignon LY, Zhu H, Shao L, Chen YW (Jul 2000). "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration". The Journal of Cell Biology. 150 (1): 177–91. doi:10.1083/jcb.150.1.177. PMC 2185563Freely accessible. PMID 10893266. 
  7. ^ Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H (Feb 2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". The Journal of Biological Chemistry. 278 (7): 5132–40. doi:10.1074/jbc.M206733200. PMID 12446731. 
  8. ^ Worthylake DK, Rossman KL, Sondek J (Dec 2000). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature. 408 (6813): 682–8. doi:10.1038/35047014. PMID 11130063. 
  9. ^ Gao Y, Xing J, Streuli M, Leto TL, Zheng Y (Dec 2001). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". The Journal of Biological Chemistry. 276 (50): 47530–41. doi:10.1074/jbc.M108865200. PMID 11595749. 
  10. ^ Buchsbaum RJ, Connolly BA, Feig LA (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". The Journal of Biological Chemistry. 278 (21): 18833–41. doi:10.1074/jbc.M207876200. PMID 12531897. 
  11. ^ Guillemot L, Paschoud S, Jond L, Foglia A, Citi S (Oct 2008). "Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions". Molecular Biology of the Cell. 19 (10): 4442–53. doi:10.1091/mbc.E08-06-0558. PMC 2555940Freely accessible. PMID 18653465. 

Further reading[edit]

External links[edit]