TIMM13

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TIMM13
Identifiers
Aliases TIMM13, TIM13, TIM13B, TIMM13A, TIMM13B, ppv1, translocase of inner mitochondrial membrane 13
External IDs MGI: 1353432 HomoloGene: 40846 GeneCards: TIMM13
RNA expression pattern
PBB GE TIMM13 218188 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012458

NM_013895

RefSeq (protein)

NP_036590

NP_038923.1
NP_038923

Location (UCSC) Chr 19: 2.43 – 2.43 Mb Chr 10: 80.9 – 80.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene.[3][4][5]

Function[edit]

This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.[5]

Interactions[edit]

TIMM13 has been shown to interact with TIMM8A.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Nov 1999). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927. 
  4. ^ Gentle IE, Perry AJ, Alcock FH, Likić VA, Dolezal P, Ng ET, Purcell AW, McConnville M, Naderer T, Chanez AL, Charrière F, Aschinger C, Schneider A, Tokatlidis K, Lithgow T (May 2007). "Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space". Molecular Biology and Evolution. 24 (5): 1149–60. doi:10.1093/molbev/msm031. PMID 17329230. 
  5. ^ a b "Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)". 
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931. 
  7. ^ Roesch K, Curran SP, Tranebjaerg L, Koehler CM (Mar 2002). "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 11 (5): 477–86. doi:10.1093/hmg/11.5.477. PMID 11875042. 

Further reading[edit]