From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Available structures
PDBOrtholog search: PDBe RCSB
AliasesTIMP3, HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3
External IDsOMIM: 188826 MGI: 98754 HomoloGene: 36322 GeneCards: TIMP3
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TIMP3
Genomic location for TIMP3
Band22q12.3Start32,801,701 bp[1]
End32,863,043 bp[1]
RNA expression pattern
PBB GE TIMP3 201149 s at fs.png

PBB GE TIMP3 201148 s at fs.png

PBB GE TIMP3 201147 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 22: 32.8 – 32.86 MbChr 10: 86.3 – 86.35 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.[5][6]

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100234 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020044 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Apte SS, Mattei MG, Olsen BR (Jun 1994). "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22". Genomics. 19 (1): 86–90. doi:10.1006/geno.1994.1016. PMID 8188246.
  6. ^ Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med. 9 (4): 407–15. doi:10.1038/nm846. PMID 12652295.
  7. ^ "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)".

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I35.003