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toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Symbol TIRAP
Entrez 114609
HUGO 17192
OMIM 606252
RefSeq NM_148910
UniProt P58753
Other data
Locus Chr. 11 q24.2

TIRAP is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

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