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Protein TLE1 PDB 1gxr.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TLE1, ESG, ESG1, GRG1, transducin like enhancer of split 1
External IDs MGI: 104636 HomoloGene: 21058 GeneCards: TLE1
RNA expression pattern
PBB GE TLE1 203222 s at fs.png

PBB GE TLE1 203221 at fs.png

PBB GE TLE1 203220 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 9: 81.58 – 81.69 Mb Chr 4: 72.12 – 72.2 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.[3][4][5]


TLE1 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry / FEBS. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415. 
  4. ^ Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Jan 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280. 
  5. ^ "Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)". 
  6. ^ Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B (Mar 2002). "The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain". Molecular and Cellular Biochemistry. 232 (1-2): 163–7. doi:10.1023/A:1014880813692. PMID 12030375. 
  7. ^ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". The Journal of Cell Biology. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829Freely accessible. PMID 11551980. 
  8. ^ a b Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11590–5. doi:10.1073/pnas.95.20.11590. PMC 21685Freely accessible. PMID 9751710. 
  9. ^ López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P (Jan 2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302. 
  10. ^ Grbavec D, Lo R, Liu Y, Stifani S (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". European Journal of Biochemistry / FEBS. 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. PMID 9874198. 
  11. ^ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929Freely accessible. PMID 9854018. 

Further reading[edit]