TLL1

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TLL1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TLL1, ASD6, TLL, tolloid like 1
External IDs MGI: 106923 HomoloGene: 49202 GeneCards: TLL1
Genetically Related Diseases
post-traumatic stress disorder, multiple sclerosis[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204760
NM_012464

NM_009390

RefSeq (protein)

NP_001191689
NP_036596

NP_033416.2
NP_033416

Location (UCSC) Chr 4: 165.87 – 166.1 Mb Chr 8: 64.01 – 64.21 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.[4][5]

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with TLL1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–5. doi:10.1159/000015412. PMID 10516436. 
  5. ^ a b "Entrez Gene: TLL1 tolloid-like 1". 

Further reading[edit]