TLR6

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TLR6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTLR6, CD286, toll like receptor 6
External IDsOMIM: 605403 MGI: 1341296 HomoloGene: 21223 GeneCards: TLR6
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for TLR6
Genomic location for TLR6
Band4p14Start38,823,715 bp[1]
End38,856,817 bp[1]
RNA expression pattern
PBB GE TLR6 207446 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006068

NM_011604
NM_001359180

RefSeq (protein)

NP_006059

NP_035734
NP_001346109

Location (UCSC)Chr 4: 38.82 – 38.86 MbChr 5: 64.95 – 64.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.[5] TLR6 has also been designated as CD286 (cluster of differentiation 286).

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174130 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051498 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene. 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569. 
  6. ^ "Entrez Gene: TLR6 toll-like receptor 6". 

Further reading[edit]

External links[edit]