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Toll-like receptor 6
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TLR6 ; CD286
External IDs OMIM605403 MGI1341296 HomoloGene21223 GeneCards: TLR6 Gene
RNA expression pattern
PBB GE TLR6 207446 at tn.png
More reference expression data
Species Human Mouse
Entrez 10333 21899
Ensembl ENSG00000174130 ENSMUSG00000051498
UniProt Q9Y2C9 Q9EPW9
RefSeq (mRNA) NM_006068 NM_011604
RefSeq (protein) NP_006059 NP_035734
Location (UCSC) Chr 4:
38.82 – 38.86 Mb
Chr 5:
64.95 – 64.96 Mb
PubMed search [1] [2]

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.[1] TLR6 has also been designated as CD286 (cluster of differentiation 286).

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.[2]


  1. ^ Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569. 
  2. ^ "Entrez Gene: TLR6 toll-like receptor 6". 

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