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Aliases TLX3, HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3
External IDs MGI: 1351209 HomoloGene: 23181 GeneCards: TLX3
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TLX3
Genomic location for TLX3
Band 5q35.1 Start 171,309,284 bp[1]
End 171,312,134 bp[1]
RNA expression pattern
PBB GE TLX3 208495 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 171.31 – 171.31 Mb Chr 11: 33.2 – 33.2 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.[5][6][7]

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164438 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040610 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (3–4): 358. doi:10.1159/000056933. PMID 11435718. 
  6. ^ Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet. 92 (3–4): 354–5. doi:10.1159/000056931. PMID 11435716. 
  7. ^ a b "Entrez Gene: TLX3 T-cell leukemia homeobox 3". 

Further reading[edit]