TMEM123

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TMEM123
Identifiers
AliasesTMEM123, KCT3, PORIMIN, PORMIN, transmembrane protein 123
External IDsOMIM: 606356 MGI: 1919179 HomoloGene: 14177 GeneCards: TMEM123
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for TMEM123
Genomic location for TMEM123
Band11q22.2Start102,396,332 bp[1]
End102,470,384 bp[1]
RNA expression pattern
PBB GE TMEM123 211967 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052932

NM_133739

RefSeq (protein)

NP_443164

NP_598500

Location (UCSC)Chr 11: 102.4 – 102.47 MbChr 9: 7.76 – 7.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Porimin is a protein that in humans is encoded by the TMEM123 gene.[5][6]

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152558 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050912 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF (Aug 2001). "Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death". Proc Natl Acad Sci U S A. 98 (17): 9778–83. doi:10.1073/pnas.171322898. PMC 55529. PMID 11481458.
  6. ^ a b "Entrez Gene: TMEM123 transmembrane protein 123".

Further reading[edit]