TMEM123

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TMEM123
Identifiers
Aliases TMEM123, KCT3, PORIMIN, PORMIN, transmembrane protein 123
External IDs MGI: 1919179 HomoloGene: 14177 GeneCards: TMEM123
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for TMEM123
Genomic location for TMEM123
Band 11q22.2 Start 102,396,332 bp[1]
End 102,470,384 bp[1]
RNA expression pattern
PBB GE TMEM123 211967 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052932

NM_133739

RefSeq (protein)

NP_443164

NP_598500

Location (UCSC) Chr 11: 102.4 – 102.47 Mb Chr 11: 7.76 – 7.79 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Porimin is a protein that in humans is encoded by the TMEM123 gene.[5][6]

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.[6]

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