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Aliases TMEM59, C1orf8, HSPC001, DCF1, PRO195, UNQ169, transmembrane protein 59
External IDs MGI: 1929278 HomoloGene: 3583 GeneCards: TMEM59
RNA expression pattern
PBB GE TMEM59 200620 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 1: 54.03 – 54.05 Mb Chr 4: 107.18 – 107.2 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.[3][4]

TMEM59 is a membrane bound protein that is localized to the Golgi apparatus.[5] The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949Freely accessible. PMID 9653160. 
  4. ^ "Entrez Gene: TMEM59 transmembrane protein 59". 
  5. ^ a b Ullrich S, Muench A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (April 2010). "The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression and secretion of the amyloid precursor protein". J Biol Chem. 285 (27): 20664–74. doi:10.1074/jbc.M109.055608. PMC 2898310Freely accessible. PMID 20427278. 

Further reading[edit]