Tropomodulin 2

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TMOD2
Identifiers
Aliases TMOD2, N-TMOD, NTMOD, tropomodulin 2
External IDs MGI: 1355335 HomoloGene: 22817 GeneCards: TMOD2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014548
NM_001142885

NM_001038710
NM_016711

RefSeq (protein)

NP_001136357
NP_055363

NP_001033799.1
NP_057920.2
NP_001033799
NP_057920

Location (UCSC) Chr 15: 51.75 – 51.82 Mb Chr 9: 75.57 – 75.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.[3]

Function[edit]

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549. 
  4. ^ "Entrez Gene: TMOD2 , Tropomodulin 2 (neuronal)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.