From Wikipedia, the free encyclopedia
Jump to: navigation, search
Tropomodulin 4 (muscle)
Symbols TMOD4 ; SK-TMOD
External IDs OMIM605834 MGI1355285 HomoloGene8355 GeneCards: TMOD4 Gene
Species Human Mouse
Entrez 29765 50874
Ensembl ENSG00000163157 ENSMUSG00000005628
UniProt Q9NZQ9 Q9JLH8
RefSeq (mRNA) NM_013353 NM_016712
RefSeq (protein) NP_037485 NP_057921
Location (UCSC) Chr 1:
151.17 – 151.18 Mb
Chr 3:
95.12 – 95.13 Mb
PubMed search [1] [2]

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.[1][2]


This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[3]


  1. ^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549. 
  2. ^ Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. doi:10.1074/jbc.274.40.28466. PMID 10497209. 
  3. ^ "Entrez Gene: TMOD4 , Tropomodulin 4 (muscle)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.