This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.
^Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID10662549.
McElhinny AS, Kolmerer B, Fowler VM et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments.". J. Biol. Chem.276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID11016930.