From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases TMUB2, FP2653, transmembrane and ubiquitin like domain containing 2
External IDs MGI: 1919303 HomoloGene: 18581 GeneCards: TMUB2
RNA expression pattern
PBB GE TMUB2 218419 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 17: 44.19 – 44.19 Mb Chr 11: 102.28 – 102.29 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.[3][4][5]


TMUB2 maps on the human chromosome 17, at locus 17q21.31.[5] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[6] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[7]


TMUB2 is likely ubiquitously expressed throughout the human body.[8] It has a high expression level that is 2.9 times higher than other human genes.[9][10]


The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[11] These will likely vary in orthologs.



TMUB1 is the only paralog of TMUB2.[12][13] These proteins share a 38% identity and 51% similarity.[14]


The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[14]

Species Common Name Accession Number Sequence Length (aa) Sequence Identity Sequence Similarity
Pan troglodytes Chimpanzee XP_003953053.1 301 100% 100%
Felis Catus Cat XP_003997025.1 322 95% 95%
Mus Musculus Mouse AAH29841.2 319 85% 88%
Alligator Mississippiensus Alligator XP_006271613.1 306 61% 71%
Haliaeetus leucocephalus Bald Eagle XP_010559728 301 59% 70%
Danio rerio Zebrafish NP_001005573.1 291 47% 60%
Acromyrmex echinatior Ant XP_011049429.1 354 23% 42%
Nannochloropsis Gaditana* Algae EWM26843.1 476 41% 54%
Coccidioides immitis RS* Pathogenic Fungus XP_001242306.1 418 38% 50%

*Limited Query Coverage

Protein Interactions[edit]

In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[15][16][17][18] Other proposed interactions include BCL2L13 (BCL2-like 13),[19] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[19] and UBQLN1 (Ubiquilin-1).[19][20][21]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474. 
  4. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146Freely accessible. PMID 9110174. 
  5. ^ a b "Entrez Gene: TMUB2 transmembrane and ubiquitin-like domain containing 2". 
  6. ^ UCSC Genome Browser: BLAT Search
  7. ^ NCBI Gene: TMUB2
  8. ^ EST Profile Viewer: Human
  9. ^ Aceview: TMUB2
  10. ^ NCBI GEO Profiles
  11. ^ SDSC Biology Workbench 2.0
  12. ^ GeneCards: TMUB2
  13. ^ NCBI Gene: TMUB1
  14. ^ a b NCBI BLAST: Basic Local Alignment Search Tool
  15. ^ Danielsen Jannie M R; Sylvestersen Kathrine B; Bekker-Jensen Simon; Szklarczyk Damian; Poulsen Jon W; Horn Heiko; Jensen Lars J; Mailand Niels; Nielsen Michael L (2011). "Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level". Molecular & Cellular Proteomics. 10 (3): M110.003590. doi:10.1074/mcp.M110.003590. PMC 3047152Freely accessible. PMID 21139048. 
  16. ^ Wagner S. A.; Beli P.; Weinert B. T.; Nielsen M. L.; Cox J.; Mann M.; Choudhary C. (2011). "A Proteome-Wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles". Molecular & Cellular Proteomics. 10: M111.013284. doi:10.1074/mcp.M111.013284. PMC 3205876Freely accessible. PMID 21890473. 
  17. ^ Kim Woong; Bennett Eric J.; Huttlin Edward L.; Guo Ailan; Li Jing; Possemato Anthony; Sowa Mathew E.; et al. (2011). "Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome". Molecular Cell. 44 (2): 325–40. doi:10.1016/j.molcel.2011.08.025. PMC 3200427Freely accessible. PMID 21906983. 
  18. ^ Povlsen Lou K.; Beli Petra; Wagner Sebastian A.; Poulsen Sara L.; Sylvestersen Kathrine B.; Poulsen Jon W.; Nielsen Michael L.; Bekker-Jensen Simon; Mailand Niels; Choudhary Chunaram (2012). "Systems-Wide Analysis of Ubiquitylation Dynamics Reveals a Key Role for PAF15 Ubiquitylation in DNA-Damage Bypass". Nature Cell Biology. 14: 1089–1098. doi:10.1038/ncb2579. 
  19. ^ a b c Rolland T, Taşan M, Charloteaux B, et al. (Nov 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–26. doi:10.1016/j.cell.2014.10.050. PMC 4266588Freely accessible. PMID 25416956. 
  20. ^ STRING: Functional Protein Association Networks
  21. ^ BioGRID Database

Further reading[edit]