Transmembrane activator and CAML interactor

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"TACI" redirects here. TACI may also refer to Total Anterior Circulation Infarct.
Tumor necrosis factor receptor superfamily, member 13B
Protein TNFRSF13B PDB 1xu1.png
PDB rendering based on 1xu1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TNFRSF13B ; CD267; CVID; CVID2; IGAD2; RYZN; TACI; TNFRSF14B
External IDs OMIM604907 MGI1889411 HomoloGene49320 GeneCards: TNFRSF13B Gene
RNA expression pattern
PBB GE TNFRSF13B 207641 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23495 57916
Ensembl ENSG00000240505 ENSMUSG00000010142
UniProt O14836 Q9ET35
RefSeq (mRNA) NM_012452 NM_021349
RefSeq (protein) NP_036584 NP_067324
Location (UCSC) Chr 17:
16.93 – 16.97 Mb
Chr 11:
61.13 – 61.15 Mb
PubMed search [1] [2]

Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene

TNFRSF13B is a transmembrane protein of the TNF receptor superfamily found predominantly on the surface of B cells, which are an important part of the immune system.[1] TACI recognizes three ligands: APRIL, BAFF and CAML.

Function[edit]

TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.

TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.

Clinical significance[edit]

TACI mutations are associated with immunodeficiency in humans, as a significant proportion of CVID patients have TACI mutations. People with this condition produce abnormally low amounts of antibodies, which are needed for protection against infections.

In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17.[1]

Interactions[edit]

TNFRSF13B has been shown to interact with B-cell activating factor,[2][3] TRAF6,[3] TRAF5,[3] TNFSF13,[2] TRAF2[3] and CAMLG.[3][4]

References[edit]

  1. ^ a b "Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B". 
  2. ^ a b Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (Nov 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646. 
  3. ^ a b c d e Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H (Jul 2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". The Journal of Experimental Medicine 192 (1): 137–43. doi:10.1084/jem.192.1.137. PMC 1887716. PMID 10880535. 
  4. ^ von Bülow GU, Bram RJ (Oct 1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily". Science 278 (5335): 138–41. doi:10.1126/science.278.5335.138. PMID 9311921. 

Further reading[edit]

  • Bossen C, Schneider P (Oct 2006). "BAFF, APRIL and their receptors: structure, function and signaling". Seminars in Immunology 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324. 
  • Treml LS, Crowley JE, Cancro MP (Oct 2006). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Seminars in Immunology 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470. 
  • Mackay F, Leung H (Oct 2006). "The role of the BAFF/APRIL system on T cell function". Seminars in Immunology 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039. 
  • Salzer U, Jennings S, Grimbacher B (Jan 2007). "To switch or not to switch--the opposing roles of TACI in terminal B cell differentiation". European Journal of Immunology 37 (1): 17–20. doi:10.1002/eji.200636914. PMID 17171762. 
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • von Bülow GU, Bram RJ (Oct 1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily". Science 278 (5335): 138–41. doi:10.1126/science.278.5335.138. PMID 9311921. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A, Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W, Clegg CH (Apr 2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease". Nature 404 (6781): 995–9. doi:10.1038/35010115. PMID 10801128. 
  • Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H (Jul 2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". The Journal of Experimental Medicine 192 (1): 137–43. doi:10.1084/jem.192.1.137. PMC 1887716. PMID 10880535. 
  • Yan M, Marsters SA, Grewal IS, Wang H, Ashkenazi A, Dixit VM (Jul 2000). "Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity". Nature Immunology 1 (1): 37–41. doi:10.1038/76889. PMID 10881172. 
  • Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A (Jun 2000). "Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI". Current Biology 10 (13): 785–8. doi:10.1016/S0960-9822(00)00566-2. PMID 10898980. 
  • von Bülow GU, Russell H, Copeland NG, Gilbert DJ, Jenkins NA, Bram RJ (Aug 2000). "Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse". Mammalian Genome 11 (8): 628–32. doi:10.1007/s003350010125. PMID 10920230. 
  • Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (Nov 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646. 
  • Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ, Sarosi I, Hsu H, Senaldi G, Theill LE (Sep 2000). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nature Immunology 1 (3): 252–6. doi:10.1038/79802. PMID 10973284. 
  • Novak AJ, Darce JR, Arendt BK, Harder B, Henderson K, Kindsvogel W, Gross JA, Greipp PR, Jelinek DF (Jan 2004). "Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival". Blood 103 (2): 689–94. doi:10.1182/blood-2003-06-2043. PMID 14512299. 
  • Hymowitz SG, Patel DR, Wallweber HJ, Runyon S, Yan M, Yin J, Shriver SK, Gordon NC, Pan B, Skelton NJ, Kelley RF, Starovasnik MA (Feb 2005). "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding". The Journal of Biological Chemistry 280 (8): 7218–27. doi:10.1074/jbc.M411714200. PMID 15542592. 
  • Moreaux J, Cremer FW, Reme T, Raab M, Mahtouk K, Kaukel P, Pantesco V, De Vos J, Jourdan E, Jauch A, Legouffe E, Moos M, Fiol G, Goldschmidt H, Rossi JF, Hose D, Klein B (Aug 2005). "The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature". Blood 106 (3): 1021–30. doi:10.1182/blood-2004-11-4512. PMC 2408610. PMID 15827134. 
  • Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS (Aug 2005). "TACI is mutant in common variable immunodeficiency and IgA deficiency". Nature Genetics 37 (8): 829–34. doi:10.1038/ng1601. PMID 16007086. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.