BAFF receptor

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  (Redirected from TNFRSF13C)
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TNFRSF13C
Protein TNFRSF13C PDB 1oqe.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTNFRSF13C, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin, tumor necrosis factor receptor superfamily member 13C, TNF receptor superfamily member 13C
External IDsMGI: 1919299 HomoloGene: 49897 GeneCards: TNFRSF13C
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TNFRSF13C
Genomic location for TNFRSF13C
Band22q13.2Start41,922,023 bp[1]
End41,926,818 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052945

NM_028075
NM_001357758

RefSeq (protein)

NP_443177

NP_082351
NP_001344687

Location (UCSC)Chr 22: 41.92 – 41.93 MbChr 15: 82.22 – 82.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a membrane protein of the TNF receptor superfamily which recognizes BAFF.[5][6] In humans it is encoded by the TNFRSF13C gene.[7]

Function[edit]

B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.[7]

Clinical significance[edit]

Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159958 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068105 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (Sep 2001). "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF". Science. 293 (5537): 2108–11. doi:10.1126/science.1061965. PMID 11509692. 
  6. ^ Yan, M; Brady, JR; Chan, B; Lee, WP; Hsu, B; Harless, S; Cancro, M; Grewal, IS; Dixit, VM (2 October 2001). "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency". Current Biology. 11 (19): 1547–52. PMID 11591325. 
  7. ^ a b c "Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C". 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.