B-cell maturation antigen

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TNFRSF17
Protein TNFRSF17 PDB 1oqd.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TNFRSF17, BCM, BCMA, CD269, TNFRSF13A, tumor necrosis factor receptor superfamily member 17
External IDs MGI: 1343050 HomoloGene: 920 GeneCards: 608
RNA expression pattern
PBB GE TNFRSF17 206641 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001192

NM_011608

RefSeq (protein)

NP_001183.2

NP_035738.1

Location (UCSC) Chr 16: 11.97 – 11.97 Mb Chr 16: 11.31 – 11.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse
BCMA TALL-1 binding domain
PDB 1oqd EBI.jpg
crystal structure of stall-1 and bcma
Identifiers
Symbol BCMA-Tall_bind
Pfam PF09257
InterPro IPR015337
SCOP 1oqd
SUPERFAMILY 1oqd

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.

TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).[1][2][3]

Function[edit]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.[3]

Interactions[edit]

TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B.[4][5] A conserved domain at the N-terminus, BCMA TALL-1 binding domain, is required for binding to the TNFSF13B.[4]

Diseases[edit]

TNFRSF17 is implicated in leukemia, lymphomas, and multiple myeloma [6] (see the "Mitelman Database" [7] and the Atlas of Genetics and Cytogenetics in Oncology and Haematology,[8]).

References[edit]

  1. ^ Laâbi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A (Nov 1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma". The EMBO Journal 11 (11): 3897–904. PMC 556899. PMID 1396583. 
  2. ^ Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (Apr 1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed". Nucleic Acids Research 22 (7): 1147–54. doi:10.1093/nar/22.7.1147. PMC 523635. PMID 8165126. 
  3. ^ a b "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17". 
  4. ^ a b Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G (May 2003). "Ligand-receptor binding revealed by the TNF family member TALL-1". Nature 423 (6935): 49–56. doi:10.1038/nature01543. PMID 12721620. 
  5. ^ Shu HB, Johnson H (Aug 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 9156–61. doi:10.1073/pnas.160213497. PMC 16838. PMID 10908663. 
  6. ^ http://atlasgeneticsoncology.org/Genes/TNFRSF17ID42616ch16p13.html
  7. ^ "Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer". 
  8. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article incorporates text from the public domain Pfam and InterPro IPR015337