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Tumor necrosis factor receptor superfamily, member 19
Symbols TNFRSF19 ; TAJ; TAJ-alpha; TRADE; TROY
External IDs OMIM606122 MGI1352474 HomoloGene8481 IUPHAR: 1891 GeneCards: TNFRSF19 Gene
Species Human Mouse
Entrez 55504 29820
Ensembl ENSG00000127863 ENSMUSG00000060548
UniProt Q9NS68 Q9JLL3
RefSeq (mRNA) NM_001204458 NM_001164155
RefSeq (protein) NP_001191387 NP_001157627
Location (UCSC) Chr 13:
23.57 – 23.68 Mb
Chr 14:
60.96 – 61.05 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively, spliced transcript variants encoding distinct isoforms have been described.[1]


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.