TNFRSF19

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
TNFRSF19
Identifiers
AliasesTNFRSF19, TAJ, TAJ-alpha, TRADE, TROY, tumor necrosis factor receptor superfamily member 19, TNF receptor superfamily member 19
External IDsMGI: 1352474 HomoloGene: 8481 GeneCards: TNFRSF19
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for TNFRSF19
Genomic location for TNFRSF19
Band13q12.12Start23,570,370 bp[1]
End23,676,104 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204458
NM_001204459
NM_018647
NM_148957
NM_001354985

NM_001164155
NM_013869

RefSeq (protein)

NP_001191387
NP_001191388
NP_061117
NP_683760
NP_001341914

NP_001157627
NP_038897

Location (UCSC)Chr 13: 23.57 – 23.68 MbChr 14: 60.96 – 61.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.[5]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively, spliced transcript variants encoding distinct isoforms have been described.[5]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.