Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively, spliced transcript variants encoding distinct isoforms have been described.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID7829101.CS1 maint: Explicit use of et al. (link)
Kojima T, Morikawa Y, Copeland NG et al. (2000). "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles". J. Biol. Chem.275 (27): 20742–7. doi:10.1074/jbc.M002691200. PMID10764796.CS1 maint: Explicit use of et al. (link)
Eby MT, Jasmin A, Kumar A et al. (2000). "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death". J. Biol. Chem.275 (20): 15336–42. doi:10.1074/jbc.275.20.15336. PMID10809768.CS1 maint: Explicit use of et al. (link)
Park JB, Yiu G, Kaneko S et al. (2005). "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors". Neuron45 (3): 345–51. doi:10.1016/j.neuron.2004.12.040. PMID15694321.CS1 maint: Explicit use of et al. (link)
Shao Z, Browning JL, Lee X et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration". Neuron45 (3): 353–9. doi:10.1016/j.neuron.2004.12.050. PMID15694322.CS1 maint: Explicit use of et al. (link)
Spanjaard RA, Whren KM, Graves C, Bhawan J (2007). "Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target". Int. J. Cancer120 (6): 1304–10. doi:10.1002/ijc.22367. PMID17187358.
Satoh J, Tabunoki H, Yamamura T et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol.33 (1): 99–107. doi:10.1111/j.1365-2990.2006.00787.x. PMID17239012.CS1 maint: Explicit use of et al. (link)