TNNC2

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TNNC2
Identifiers
Aliases TNNC2
External IDs MGI: 98780 HomoloGene: 55727 GeneCards: TNNC2
RNA expression pattern
PBB GE TNNC2 205388 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003279

NM_009394

RefSeq (protein)

NP_003270

NP_033420.1
NP_033420

Location (UCSC) Chr 20: 45.82 – 45.83 Mb Chr 2: 164.78 – 164.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.[3][4]

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem. 265 (21): 12520–8. PMID 2373703. 
  4. ^ a b "Entrez Gene: TNNC2 troponin C type 2 (fast)". 

Further reading[edit]