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Troponin C type 2 (fast)
PBB Protein TNNI2 image.jpg
PDB rendering based on 1a2x.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol TNNC2
External IDs OMIM191039 MGI98780 HomoloGene55727 GeneCards: TNNC2 Gene
RNA expression pattern
PBB GE TNNC2 205388 at tn.png
More reference expression data
Species Human Mouse
Entrez 7125 21925
Ensembl ENSG00000101470 ENSMUSG00000017300
UniProt P02585 P20801
RefSeq (mRNA) NM_003279 NM_009394
RefSeq (protein) NP_003270 NP_033420
Location (UCSC) Chr 20:
45.82 – 45.83 Mb
Chr 2:
164.78 – 164.78 Mb
PubMed search [1] [2]

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.[1][2]

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.[2]


  1. ^ Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem 265 (21): 12520–8. PMID 2373703. 
  2. ^ a b "Entrez Gene: TNNC2 troponin C type 2 (fast)". 

Further reading[edit]