TNS1

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TNS1
Identifiers
AliasesTNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDsOMIM: 600076 MGI: 104552 HomoloGene: 11219 GeneCards: TNS1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for TNS1
Genomic location for TNS1
Band2q35Start217,799,789 bp[1]
End218,002,995 bp[1]
RNA expression pattern
PBB GE TNS1 218864 at fs.png

PBB GE TNS1 221246 x at fs.png

PBB GE TNS1 218863 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308022
NM_001308023
NM_022648

NM_001289895
NM_027884
NM_177169

RefSeq (protein)

NP_001294951
NP_001294952
NP_072174
NP_001294951.1
NP_001294952.1

n/a

Location (UCSC)Chr 2: 217.8 – 218 MbChr 1: 73.91 – 74.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.[5]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079308 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055322 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TNS1 tensin 1".

External links[edit]

Further reading[edit]