Topoisomerase (DNA) I
rendering based on 1a31.
PDB Ortholog search:
List of PDB id codes
, 1A31 , 1A35 , 1A36 , 1EJ9 , 1K4S , 1K4T , 1LPQ , 1NH3 , 1R49 , 1RR8 , 1RRJ , 1SC7 , 1SEU , 1T8I 1TL8
; TOPI TOP1
OMIM: 126420 MGI: 98788 HomoloGene: 2467 ChEMBL: 1781 GeneCards: TOP1 Gene
41.03 – 41.12 Mb
160.65 – 160.72 Mb
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.
Function [ edit ]
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Interactions [ edit ]
TOP1 has been shown to
See also [ edit ]
References [ edit ]
^ "Entrez Gene: TOP1 topoisomerase (DNA) I".
^ Labourier E, Rossi F, Gallouzi IE, Allemand E, Divita G, Tazi J (Jun 1998). "Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor". Nucleic Acids Research 26 (12): 2955–62. PMC 147637. PMID 9611241.
^ Andersen FF, Tange TØ, Sinnathamby T, Olesen JR, Andersen KE, Westergaard O et al. (Sep 2002). "The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation". Journal of Molecular Biology 322 (4): 677–86. PMID 12270705.
^ a b Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y et al. "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics 3: 1. PMC 64781. PMID 11818025.
^ Haluska P, Saleem A, Edwards TK, Rubin EH (Apr 1998). "Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen". Nucleic Acids Research 26 (7): 1841–7. PMC 147454. PMID 9512561.
^ Bharti AK, Olson MO, Kufe DW, Rubin EH (Jan 1996). "Identification of a nucleolin binding site in human topoisomerase I". The Journal of Biological Chemistry 271 (4): 1993–7. PMID 8567649.
^ Gobert C, Skladanowski A, Larsen AK (Aug 1999). "The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53". Proceedings of the National Academy of Sciences of the United States of America 96 (18): 10355–60. PMC 17892. PMID 10468612.
^ Mao Y, Mehl IR, Muller MT (Feb 2002). "Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status". Proceedings of the National Academy of Sciences of the United States of America 99 (3): 1235–40. doi: 10.1073/pnas.022631899. PMC 122173. PMID 11805286.
^ Mao Y, Sun M, Desai SD, Liu LF (Apr 2000). "SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage". Proceedings of the National Academy of Sciences of the United States of America 97 (8): 4046–51. doi: 10.1073/pnas.080536597. PMC 18143. PMID 10759568.
Further reading [ edit ]
1a31: HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
1a35: HUMAN TOPOISOMERASE I/DNA COMPLEX
1a36: TOPOISOMERASE I/DNA COMPLEX
1ej9: CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
1k4s: HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
1k4t: HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
1lpq: Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion
1nh3: Human Topoisomerase I Ara-C Complex
1r49: Human topoisomerase I (Topo70) double mutant K532R/Y723F
1rr8: Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
1rrj: Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
1sc7: Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex
1seu: Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex
1t8i: Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex
1tl8: Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex