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Two pore segment channel 1
Symbols TPCN1 ; TPC1
External IDs OMIM609666 MGI2182472 HomoloGene9905 IUPHAR: 392 GeneCards: TPCN1 Gene
Species Human Mouse
Entrez 53373 252972
Ensembl ENSG00000186815 ENSMUSG00000032741
UniProt Q9ULQ1 Q9EQJ0
RefSeq (mRNA) NM_001143819 NM_145853
RefSeq (protein) NP_001137291 NP_665852
Location (UCSC) Chr 12:
113.22 – 113.3 Mb
Chr 5:
120.53 – 120.59 Mb
PubMed search [1] [2]

Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene.[1] The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).[2][3][4]

See also[edit]


  1. ^ "Entrez Gene: two pore segment channel 1". 
  2. ^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (October 1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461. 
  3. ^ Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochem. Biophys. Res. Commun. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID 10753632. 
  4. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 

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